Endocrine Abstracts

The majority of adrenocortical carcinomas (ACC) overexpress insulin-like growth factor 2 (IGF2). Although IGF2 drives a proliferative autocrine loop by binding to IGF1R and the isoform A of the insulin receptor (IRA), most studies focused on IGF1R. Recently, a high expression of IRA was observed in ACC vs normal adrenal tissues (NA), suggesting its potential involvement in modulating IGF2 effects in adrenocortical tumorigenesis. Aim of this study was to investigate the specifi...

The cytoskeletal acting-binding protein filamin A (FLNA) is poorly expressed in adrenocortical carcinomas (ACC) compared to adenomas (ACA), and this might contribute to sustain the increased cell proliferation by upregulating IGF1R and its downstream signaling. An increased expression of the CDK1 kinase Wee1, a leading gatekeeper for G2/M transition, was shown in mouse neural progenitor cells after loss of FLNA. Wee1 is highly expressed in several tumor types and its pharmacol...

Adrenocortical carcinomas (ACC) overexpress the insulin-like growth factor 2 (IGF2) that drives a proliferative autocrine loop by binding both IGF1R and isoform A of insulin receptor (IRA). However, the contribution of these receptors in mediating ACC cell growth has been poorly investigated. The aim of this study was to investigate IGF1R and IR expression and localisation in ACC and adrenocortical adenomas (ACA) samples, and to test their involvement in mediating IGF2 tumorig...